Unlike Gwendolyn or other names, which I love but are more guilty pleasures for someone not in an English speaking country like me, Irene is in my list since long and ACTUALLY on my perfectly usable + beautiful want to use list! It is very modern here and I hear it on children and teens, but I still love it.
I would use:
Irene Alexandra / Irene Alessandra
Irene Mei
Irene Costanza
Irene Zoe
Irene Larissa
Irene Clara
Irene Mabel (kinda gp but would love)
Irene Alice
Irene Felicity / Irene Felicita
Irene Silvia
Irene Adelaide 
Irene Giulietta / Irene Juliette
Irene Teresa
Irene Bianca
Irene Heloria
Irene Andromeda 
Irene Cassiopeia
Irene Luisa
Irene Anna Ludmilla
Irene Emilia
Irene Margot / Irene Margaux (last one kinda gp but would love)
Irene Calliope
Irene Gaia
Irene Pasifae (it spelling) / Irene Pasiphaë
Irene Cassandra
Irene Ludovica
Irene Circe
Irene Angelica
Irene Isidora / Isadora
Irene Lavinia
Irene Flaminia
Irene and:
Gaia, Elisabeth, Achille, Paride / Paris (b), Hector / Ettore, Aurelio, Flavio, Bruno, Jules / Julius, Lysander (if I lived in an English speaking country) / Lisandro (this spelling honours grandma), Alexander / Alessandro, Alexei / Alessio / Alexis (b), Evander / Evandro, Angelica, Olimpia, Cassandra, Horatio (lived I out of Italy or Spain, here the H is silent…), Isidora / Isadora 


(Imagine Irene and Isadora!), Lavinia, maybe Flaminia, Allegra, Serena (g) / Sereno (b), Ocean(o) for a boy, and most Ancient Greek or Roman inspired names.
I use the Italian / German prn Ee-REH-neh but use the British one for Irene Mabel and Irene Alice!
My situation is different from you, so I listed both names I would use in my country and in another life in a place where the H or other sounds won’t get silented for example or too difficult to spell.
Love Irene!