Personally, I think of that creepy little kid from the Childen of the Corn! But I have an 8 month old cousin named [name]Issac[/name], and he’s a doll. Everytime I see him, I still wanna shout “MALACHAI!!” though.
My impressions is intelligent and religious.
I think of [name]Isaac[/name] Mendes in the show “Heros” 
It’s a fine name but I wouldn’t choose it, just don’t like the sound.
I think of someone who is wiry, dark-haired and smart as a whip.
I think perhaps a bit nerdy, or alternative…
I once thought it was too biblical but it grew on me so much in the last year that I chose the name for my newborn son! I think it is strong and handsome and masculine but not macho. It has history, a strong sound, is multi-cultural and I can see it on a doctor, an artist or anything in between…I just love the name!
[name]Isaac[/name] is my sons name, so im partial to it! 
I def think there is something to a name, and, the name certainly fits. He’s 3 years old, Very handsome (he’s won several BIG photo contests), he’s above average intelligence according to his preschool teachers, creative, active, laughs alot, looks after his 1 year old sister already and clearly loves her. But, he’s def got a dare devil streak, and likes to test his limits (yup, a bit of a rebel). It’s pretty much what i suspected i guess.
Handsome, reliable, dependent, a charmer, a wonderful smile, a caring father someday.
Also, red-hair or blondish. My ex-boyfriend was named [name]Isaac[/name], but I didn’t base the above on him. I’d thought of the name [name]Isaac[/name] for a character long before I met him. 
I think it’s a great name, love the meaning too.
Although I like the name [name]Isaac[/name], I can never forget a boy who was bullied by others chanting “I sick, I sick, I sick.”